TargetNet
Q14432
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Function
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q14432 |
| PDB | 1LRC |
| BioGrid | 111165 |
| BindingDB | Q14432 |
| DrugBank | DB01223, DB01427, DB00261, DB01166, DB04880, DB00235, DB00277 |
| Guide to PHARMACOLOGY | 1298 |
| PharmGKB | PA33126 |
| KEGG | hsa:5139 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5139 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8859 | 0.0077 |
| Accuracy | 0.8091 | 0.0204 |
| Sensitivity | 0.8054 | 0.021 |
| Specificity | 0.8135 | 0.0298 |
| BEDROC | 0.9934 | 0.0031 |
| MCC Threshold | 0.73 | N/A |
| MCC | 0.6326 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.8312 | N/A |