TargetNet
Q14416
Metabotropic glutamate receptor 2
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Database Links
| Database | Links |
|---|---|
| UniProt | Q14416 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q14416 |
| DrugBank | DB00659, DB00184 |
| Guide to PHARMACOLOGY | 290 |
| PharmGKB | PA28991 |
| KEGG | hsa:2912 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2912 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9722 | 0.0029 |
| Accuracy | 0.9351 | 0.0055 |
| Sensitivity | 0.9549 | 0.0069 |
| Specificity | 0.9141 | 0.0054 |
| BEDROC | 0.9947 | 0.004 |
| MCC Threshold | 0.528 | N/A |
| MCC | 0.8824 | N/A |
| F-score Threshold | 0.528 | N/A |
| F-score | 0.9437 | N/A |