TargetNet
Q13946
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
Database Links
| Database | Links |
|---|---|
| UniProt | Q13946 |
| PDB | 1ZKL, 3G3N |
| BioGrid | 111176 |
| BindingDB | Q13946 |
| DrugBank | DB00651, DB00920 |
| Guide to PHARMACOLOGY | 1305 |
| PharmGKB | PA33139 |
| KEGG | hsa:5150 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5150 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9781 | 0.0017 |
| Accuracy | 0.9593 | 0.0037 |
| Sensitivity | 0.9345 | 0.0065 |
| Specificity | 0.9806 | 0.0029 |
| BEDROC | 0.9998 | 6.9128 × 10-5 |
| MCC Threshold | 0.556 | N/A |
| MCC | 0.9112 | N/A |
| F-score Threshold | 0.404 | N/A |
| F-score | 0.9505 | N/A |