TargetNet
Q13639
5-hydroxytryptamine receptor 4
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | Q13639 |
| PDB | Not available |
| BioGrid | 109592 |
| BindingDB | Q13639 |
| DrugBank | DB00604, DB00953, DB01079, DB00315 |
| Guide to PHARMACOLOGY | 9 |
| PharmGKB | PA29557 |
| KEGG | hsa:3360 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3360 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9784 | 0.0015 |
| Accuracy | 0.9418 | 0.003 |
| Sensitivity | 0.9256 | 0.004 |
| Specificity | 0.9602 | 0.0039 |
| BEDROC | 0.9954 | 0.0025 |
| MCC Threshold | 0.362 | N/A |
| MCC | 0.9022 | N/A |
| F-score Threshold | 0.362 | N/A |
| F-score | 0.9545 | N/A |