TargetNet
Q13627
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Function
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1.
Database Links
| Database | Links |
|---|---|
| UniProt | Q13627 |
| PDB | 2VX3, 2WO6, 3ANQ, 3ANR, 4AZE, 4MQ1, 4MQ2 |
| BioGrid | 108192 |
| BindingDB | Q13627 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2009 |
| PharmGKB | PA27545 |
| KEGG | hsa:1859 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1859 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8089 | 0.0135 |
| Accuracy | 0.7359 | 0.0175 |
| Sensitivity | 0.6341 | 0.034 |
| Specificity | 0.8231 | 0.0157 |
| BEDROC | 0.9237 | 0.0576 |
| MCC Threshold | 0.5 | N/A |
| MCC | 0.5355 | N/A |
| F-score Threshold | 0.42 | N/A |
| F-score | 0.7547 | N/A |