TargetNet
Q13258
Prostaglandin D2 receptor
Function
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q13258 |
| PDB | Not available |
| BioGrid | 111701 |
| BindingDB | Q13258 |
| DrugBank | DB00716 |
| Guide to PHARMACOLOGY | 338 |
| PharmGKB | PA285 |
| KEGG | hsa:5729 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5729 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9819 | 0.0018 |
| Accuracy | 0.9471 | 0.003 |
| Sensitivity | 0.9311 | 0.0043 |
| Specificity | 0.9609 | 0.0046 |
| BEDROC | 0.9977 | 0.0026 |
| MCC Threshold | 0.522 | N/A |
| MCC | 0.894 | N/A |
| F-score Threshold | 0.46 | N/A |
| F-score | 0.9423 | N/A |