TargetNet
Q13224
Glutamate receptor ionotropic, NMDA 2B
Function
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q13224 |
| PDB | 1S11, 1S2S, 2IPV |
| BioGrid | 109161 |
| BindingDB | Q13224 |
| DrugBank | DB00949, DB00502, DB00142, DB00836, DB01043 |
| Guide to PHARMACOLOGY | 457 |
| PharmGKB | PA28980 |
| KEGG | hsa:2904 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2904 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9637 | 0.0048 |
| Accuracy | 0.9149 | 0.0082 |
| Sensitivity | 0.9343 | 0.0084 |
| Specificity | 0.8955 | 0.0134 |
| BEDROC | 0.9543 | 0.0164 |
| MCC Threshold | 0.492 | N/A |
| MCC | 0.8312 | N/A |
| F-score Threshold | 0.492 | N/A |
| F-score | 0.9167 | N/A |