TargetNet
Q13133
Oxysterols receptor LXR-alpha
Function
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q13133 |
| PDB | 1UHL, 3IPQ, 3IPS, 3IPU |
| BioGrid | 115373 |
| BindingDB | Q13133 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 602 |
| PharmGKB | PA31751 |
| KEGG | hsa:10062 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 10062 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9679 | 0.0021 |
| Accuracy | 0.9174 | 0.0046 |
| Sensitivity | 0.9239 | 0.0061 |
| Specificity | 0.9111 | 0.0059 |
| BEDROC | 0.9931 | 0.002 |
| MCC Threshold | 0.52 | N/A |
| MCC | 0.8323 | N/A |
| F-score Threshold | 0.52 | N/A |
| F-score | 0.9162 | N/A |