TargetNet
Q13093
Platelet-activating factor acetylhydrolase
Function
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Database Links
| Database | Links |
|---|---|
| UniProt | Q13093 |
| PDB | 3D59, 3D5E, 3F96, 3F97, 3F98, 3F9C |
| BioGrid | 113667 |
| BindingDB | Q13093 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1432 |
| PharmGKB | PA33368 |
| KEGG | hsa:7941 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7941 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.991 | 0.0016 |
| Accuracy | 0.9647 | 0.0063 |
| Sensitivity | 0.9675 | 0.009 |
| Specificity | 0.9621 | 0.0055 |
| BEDROC | 0.9963 | 0.007 |
| MCC Threshold | 0.31 | N/A |
| MCC | 0.9426 | N/A |
| F-score Threshold | 0.31 | N/A |
| F-score | 0.9698 | N/A |