TargetNet
Q13085
Acetyl-CoA carboxylase 1
Function
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Database Links
| Database | Links |
|---|---|
| UniProt | Q13085 |
| PDB | 2YL2, 3COJ, 4ASI |
| BioGrid | 106549 |
| BindingDB | Q13085 |
| DrugBank | DB00121 |
| Guide to PHARMACOLOGY | 1263 |
| PharmGKB | PA24421 |
| KEGG | hsa:31 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 31 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8581 | 0.0059 |
| Accuracy | 0.7887 | 0.0096 |
| Sensitivity | 0.8298 | 0.018 |
| Specificity | 0.7383 | 0.0219 |
| BEDROC | 0.9662 | 0.0131 |
| MCC Threshold | 0.536 | N/A |
| MCC | 0.5902 | N/A |
| F-score Threshold | 0.536 | N/A |
| F-score | 0.8143 | N/A |