TargetNet
Q12809
Potassium voltage-gated channel subfamily H member 2
Function
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Database Links
| Database | Links |
|---|---|
| UniProt | Q12809 |
| PDB | 1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA |
| BioGrid | 109959 |
| BindingDB | Q12809 |
| DrugBank | DB01118, DB00276, DB00637, DB01136, DB00604, DB00204, DB01218, DB00308, DB01100, DB01182, DB00908, DB06144, DB00489, DB00342, DB00661 |
| Guide to PHARMACOLOGY | 572 |
| PharmGKB | PA212 |
| KEGG | hsa:3757 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3757 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8779 | 0.0017 |
| Accuracy | 0.804 | 0.0012 |
| Sensitivity | 0.7842 | 0.0047 |
| Specificity | 0.8221 | 0.0036 |
| BEDROC | 0.9681 | 0.0032 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.6087 | N/A |
| F-score Threshold | 0.414 | N/A |
| F-score | 0.7993 | N/A |