TargetNet
Q08499
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Database Links
| Database | Links |
|---|---|
| UniProt | Q08499 |
| PDB | 1E9K, 1MKD, 1OYN, 1PTW, 1Q9M, 1TB7, 1TBB, 1XOM, 1XON, 1XOQ, 1XOR, 1Y2B, 1Y2C, 1Y2D, 1Y2E, 1Y2K, 1ZKN, 2FM0, 2FM5, 2PW3, 2QYN, 3G4G, 3G4I, 3G4K, 3G4L, 3G58, 3IAD, 3IAK, 3K4S, 3SL3, 3SL4, 3SL5, 3SL6, 3SL8, 3V9B |
| BioGrid | 111170 |
| BindingDB | Q08499 |
| DrugBank | DB00131, DB00651 |
| Guide to PHARMACOLOGY | 1303 |
| PharmGKB | PA33130 |
| KEGG | hsa:5144 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5144 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9479 | 0.0042 |
| Accuracy | 0.9106 | 0.0047 |
| Sensitivity | 0.8902 | 0.0072 |
| Specificity | 0.9298 | 0.0088 |
| BEDROC | 0.9925 | 0.0096 |
| MCC Threshold | 0.588 | N/A |
| MCC | 0.8083 | N/A |
| F-score Threshold | 0.516 | N/A |
| F-score | 0.8992 | N/A |