TargetNet
Q07869
Peroxisome proliferator-activated receptor alpha
Function
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
Database Links
| Database | Links |
|---|---|
| UniProt | Q07869 |
| PDB | 1I7G, 1K7L, 1KKQ, 2NPA, 2P54, 2REW, 2ZNN, 3ET1, 3FEI, 3G8I, 3KDT, 3KDU, 3SP6, 3VI8, 4BCR |
| BioGrid | 111461 |
| BindingDB | Q07869 |
| DrugBank | DB01076, DB01393, DB00636, DB01039, DB01241, DB00641 |
| Guide to PHARMACOLOGY | 593 |
| PharmGKB | PA280 |
| KEGG | hsa:5465 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5465 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9589 | 0.0014 |
| Accuracy | 0.9131 | 0.0026 |
| Sensitivity | 0.9321 | 0.0051 |
| Specificity | 0.893 | 0.0024 |
| BEDROC | 0.9933 | 0.0022 |
| MCC Threshold | 0.406 | N/A |
| MCC | 0.8272 | N/A |
| F-score Threshold | 0.406 | N/A |
| F-score | 0.9182 | N/A |