TargetNet
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
Function
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Database Links
| Database | Links |
|---|---|
| UniProt | Q07820 |
| PDB | 2KBW, 2NL9, 2NLA, 2PQK, 3D7V, 3IO9, 3KJ0, 3KJ1, 3KJ2, 3KZ0, 3MK8, 3PK1, 3TWU, 3WIX, 3WIY, 4HW2, 4HW3, 4HW4 |
| BioGrid | 110338 |
| BindingDB | Q07820 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA30688 |
| KEGG | hsa:4170 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4170 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8685 | 0.0054 |
| Accuracy | 0.8055 | 0.0052 |
| Sensitivity | 0.7187 | 0.012 |
| Specificity | 0.8836 | 0.0102 |
| BEDROC | 0.9925 | 0.0018 |
| MCC Threshold | 0.594 | N/A |
| MCC | 0.6638 | N/A |
| F-score Threshold | 0.44 | N/A |
| F-score | 0.8009 | N/A |