TargetNet
Q07817
Bcl-2-like protein 1
Function
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Database Links
| Database | Links |
|---|---|
| UniProt | Q07817 |
| PDB | 1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4EHR, 4HNJ, 4IEH |
| BioGrid | 107070 |
| BindingDB | Q07817 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA76 |
| KEGG | hsa:598 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 598 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9495 | 0.0039 |
| Accuracy | 0.8932 | 0.0078 |
| Sensitivity | 0.8776 | 0.0076 |
| Specificity | 0.9101 | 0.0111 |
| BEDROC | 0.9835 | 0.0075 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8086 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9077 | N/A |