TargetNet
Q07343
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Database Links
| Database | Links |
|---|---|
| UniProt | Q07343 |
| PDB | 1F0J, 1JP1, 1JP2, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ |
| BioGrid | 111168 |
| BindingDB | Q07343 |
| DrugBank | DB00131, DB01427, DB00201, DB01166, DB00651, DB00824, DB01113, DB00806, DB00277 |
| Guide to PHARMACOLOGY | 1301 |
| PharmGKB | PA33129 |
| KEGG | hsa:5142 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5142 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9753 | 0.0014 |
| Accuracy | 0.9474 | 0.0044 |
| Sensitivity | 0.9417 | 0.0067 |
| Specificity | 0.9532 | 0.0049 |
| BEDROC | 0.9921 | 0.0043 |
| MCC Threshold | 0.614 | N/A |
| MCC | 0.8876 | N/A |
| F-score Threshold | 0.538 | N/A |
| F-score | 0.9428 | N/A |