TargetNet
Q05941
Neuronal acetylcholine receptor subunit alpha-7
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Database Links
| Database | Links |
|---|---|
| UniProt | Q05941 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q05941 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 468 |
| PharmGKB | Not available |
| KEGG | rno:25302 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25302 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9484 | 0.0033 |
| Accuracy | 0.8943 | 0.0048 |
| Sensitivity | 0.9084 | 0.0066 |
| Specificity | 0.8767 | 0.0072 |
| BEDROC | 0.9829 | 0.0053 |
| MCC Threshold | 0.49 | N/A |
| MCC | 0.7966 | N/A |
| F-score Threshold | 0.438 | N/A |
| F-score | 0.909 | N/A |