TargetNet
Q05769
Prostaglandin G/H synthase 2
Function
Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Critical component of colonic mucosal wound repair.
Database Links
| Database | Links |
|---|---|
| UniProt | Q05769 |
| PDB | 1CVU, 1CX2, 1DCX, 1DD0, 1DDX, 1PXX, 3HS5, 3HS6, 3HS7, 3KRK, 3LN0, 3LN1, 3MDL, 3MQE, 3NT1, 3NTB, 3NTG, 3OLT, 3OLU, 3PGH, 3Q7D, 3QH0, 3QMO, 3RR3, 3TZI, 4COX, 4E1G, 4FM5, 4LLZ, 4M10, 4M11, 5COX, 6COX |
| BioGrid | 202463 |
| BindingDB | Q05769 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | mmu:19225 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 19225 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9439 | 0.0036 |
| Accuracy | 0.8872 | 0.0035 |
| Sensitivity | 0.9203 | 0.0093 |
| Specificity | 0.8539 | 0.0068 |
| BEDROC | 0.9533 | 0.0208 |
| MCC Threshold | 0.466 | N/A |
| MCC | 0.7781 | N/A |
| F-score Threshold | 0.466 | N/A |
| F-score | 0.8925 | N/A |