TargetNet
Q05469
Hormone-sensitive lipase
Function
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Database Links
| Database | Links |
|---|---|
| UniProt | Q05469 |
| PDB | Not available |
| BioGrid | 110179 |
| BindingDB | Q05469 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2593 |
| PharmGKB | PA30393 |
| KEGG | hsa:3991 |
| BioCyc | MetaCyc:HS01328-MONOMER |
| Entrez Gene (GeneID) | 3991 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9899 | 0.0031 |
| Accuracy | 0.9689 | 0.0025 |
| Sensitivity | 0.9824 | 0.0021 |
| Specificity | 0.9524 | 0.0038 |
| BEDROC | 0.9994 | 0.0012 |
| MCC Threshold | 0.566 | N/A |
| MCC | 0.9513 | N/A |
| F-score Threshold | 0.566 | N/A |
| F-score | 0.978 | N/A |