TargetNet
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Function
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Database Links
| Database | Links |
|---|---|
| UniProt | Q04631 |
| PDB | 1D8D, 1D8E, 1FPP, 1FT1, 1FT2, 1FTI, 1HZ7, 1JCR, 1JCS, 1KZO, 1KZP, 1KZR, 1N4P, 1N4Q, 1N4R, 1N4S, 1N94, 1N95, 1N9A, 1NI1, 1NL4, 1O1R, 1O1S, 1O1T, 1O5M, 1QBQ, 1QE2, 1S64, 1SA5, 1TN7, 1TN8, 1TNB, 1TNO, 1TNU, 1TNY, 1TNZ, 1X81, 2BED, 2FTI, 2R2L, 2ZIR, 2ZIS, 3DPY, 3E30, 3E32, 3E33, 3E34, 3EU5, 3EUV, 3FTI, 3KSL, 3KSQ, 4GTM, 4GTO, 4GTP, 4GTQ, 4GTR |
| BioGrid | Not available |
| BindingDB | Q04631 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:25318 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25318 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9823 | 0.0033 |
| Accuracy | 0.9492 | 0.0078 |
| Sensitivity | 0.9516 | 0.0138 |
| Specificity | 0.9467 | 0.0079 |
| BEDROC | 0.9999 | 2.0287 × 10-5 |
| MCC Threshold | 0.492 | N/A |
| MCC | 0.9085 | N/A |
| F-score Threshold | 0.492 | N/A |
| F-score | 0.9548 | N/A |