TargetNet
Q04609
Glutamate carboxypeptidase 2
Function
Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
Database Links
| Database | Links |
|---|---|
| UniProt | Q04609 |
| PDB | 1Z8L, 2C6C, 2C6G, 2C6P, 2CIJ, 2JBJ, 2JBK, 2OOT, 2OR4, 2PVV, 2PVW, 2XEF, 2XEG, 2XEI, 2XEJ, 3BHX, 3BI0, 3BI1, 3BXM, 3D7D, 3D7F, 3D7G, 3D7H, 3IWW, 3RBU, 3SJE, 3SJF, 3SJG, 3SJX |
| BioGrid | 108630 |
| BindingDB | Q04609 |
| DrugBank | DB00089, DB00142 |
| Guide to PHARMACOLOGY | 1606 |
| PharmGKB | PA28205 |
| KEGG | hsa:2346 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2346 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9563 | 0.0059 |
| Accuracy | 0.9026 | 0.0088 |
| Sensitivity | 0.9438 | 0.0125 |
| Specificity | 0.8562 | 0.0098 |
| BEDROC | 0.9899 | 0.0066 |
| MCC Threshold | 0.48 | N/A |
| MCC | 0.8392 | N/A |
| F-score Threshold | 0.48 | N/A |
| F-score | 0.9263 | N/A |