TargetNet
Q03181
Peroxisome proliferator-activated receptor delta
Function
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Database Links
| Database | Links |
|---|---|
| UniProt | Q03181 |
| PDB | 1GWX, 1Y0S, 2AWH, 2B50, 2BAW, 2ENV, 2GWX, 2J14, 2Q5G, 2XYJ, 2XYW, 2XYX, 2ZNP, 2ZNQ, 3D5F, 3DY6, 3ET2, 3GWX, 3GZ9, 3OZ0, 3PEQ, 3SP9, 3TKM |
| BioGrid | 111463 |
| BindingDB | Q03181 |
| DrugBank | DB00159, DB00605, DB00374 |
| Guide to PHARMACOLOGY | 594 |
| PharmGKB | PA33557 |
| KEGG | hsa:5467 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5467 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9521 | 0.0018 |
| Accuracy | 0.9077 | 0.0022 |
| Sensitivity | 0.9116 | 0.004 |
| Specificity | 0.9043 | 0.0032 |
| BEDROC | 0.9488 | 0.0079 |
| MCC Threshold | 0.398 | N/A |
| MCC | 0.8317 | N/A |
| F-score Threshold | 0.398 | N/A |
| F-score | 0.9122 | N/A |