TargetNet
Q02127
Dihydroorotate dehydrogenase (quinone), mitochondrial
Function
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Database Links
| Database | Links |
|---|---|
| UniProt | Q02127 |
| PDB | 1D3G, 1D3H, 2B0M, 2BXV, 2FPT, 2FPV, 2FPY, 2FQI, 2PRH, 2PRL, 2PRM, 2WV8, 3F1Q, 3FJ6, 3FJL, 3G0U, 3G0X, 3KVJ, 3KVK, 3KVL, 3KVM, 3U2O, 3ZWS, 3ZWT, 4IGH |
| BioGrid | 108068 |
| BindingDB | Q02127 |
| DrugBank | DB01117, DB01097 |
| Guide to PHARMACOLOGY | 2604 |
| PharmGKB | PA27327 |
| KEGG | hsa:1723 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1723 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9619 | 0.0042 |
| Accuracy | 0.9174 | 0.0056 |
| Sensitivity | 0.8787 | 0.0086 |
| Specificity | 0.9502 | 0.008 |
| BEDROC | 0.9969 | 0.0079 |
| MCC Threshold | 0.516 | N/A |
| MCC | 0.8455 | N/A |
| F-score Threshold | 0.482 | N/A |
| F-score | 0.9119 | N/A |