Voltage-dependent N-type calcium channel subunit alpha-1B
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Database | Links |
---|---|
UniProt | Q00975 |
PDB | 2LCM |
BioGrid | 107228 |
BindingDB | Q00975 |
DrugBank | DB00381, DB00996 |
Guide to PHARMACOLOGY | 533 |
PharmGKB | PA26008 |
KEGG | hsa:774 |
BioCyc | Not available |
Entrez Gene (GeneID) | 774 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.7846 | 0.007 |
Accuracy | 0.737 | 0.009 |
Sensitivity | 0.5722 | 0.008 |
Specificity | 0.8819 | 0.0133 |
BEDROC | 0.9897 | 0.0013 |
MCC Threshold | 0.692 | N/A |
MCC | 0.5418 | N/A |
F-score Threshold | 0.376 | N/A |
F-score | 0.6903 | N/A |