TargetNet
Q00960
Glutamate receptor ionotropic, NMDA 2B
Function
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q00960 |
| PDB | 3JPW, 3JPY, 3QEL, 3QEM |
| BioGrid | 246575 |
| BindingDB | Q00960 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:24410 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24410 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9576 | 0.0057 |
| Accuracy | 0.9185 | 0.0058 |
| Sensitivity | 0.9269 | 0.0034 |
| Specificity | 0.9092 | 0.0101 |
| BEDROC | 0.9867 | 0.0065 |
| MCC Threshold | 0.512 | N/A |
| MCC | 0.8381 | N/A |
| F-score Threshold | 0.486 | N/A |
| F-score | 0.9238 | N/A |