Fatty-acid amide hydrolase 1
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
Database | Links |
---|---|
UniProt | P97612 |
PDB | 1MT5, 2VYA, 2WAP, 2WJ1, 2WJ2, 3K7F, 3K83, 3K84, 3LJ6, 3LJ7, 3OJ8, 3PPM, 3PR0, 3QJ8, 3QJ9, 3QK5, 3QKV, 4DO3, 4HBP, 4J5P |
BioGrid | Not available |
BindingDB | P97612 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | Not available |
KEGG | rno:100911581, rno:29347 |
BioCyc | Not available |
Entrez Gene (GeneID) | 100911581, 29347 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9458 | 0.0016 |
Accuracy | 0.8894 | 0.004 |
Sensitivity | 0.8913 | 0.0059 |
Specificity | 0.8875 | 0.0036 |
BEDROC | 0.9904 | 0.0027 |
MCC Threshold | 0.498 | N/A |
MCC | 0.7828 | N/A |
F-score Threshold | 0.498 | N/A |
F-score | 0.8889 | N/A |