TargetNet
P80457
Xanthine dehydrogenase/oxidase
Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
Database Links
| Database | Links |
|---|---|
| UniProt | P80457 |
| PDB | 1FIQ, 1FO4, 1N5X, 1V97, 1VDV, 3AM9, 3AMZ, 3AX7, 3AX9, 3B9J, 3BDJ, 3ETR, 3EUB, 3NRZ, 3NS1, 3NVV, 3NVW, 3NVY, 3NVZ, 3SR6, 3UNA, 3UNC, 3UNI |
| BioGrid | Not available |
| BindingDB | P80457 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:280960 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 280960 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9397 | 0.0027 |
| Accuracy | 0.8521 | 0.0104 |
| Sensitivity | 0.836 | 0.0194 |
| Specificity | 0.8661 | 0.017 |
| BEDROC | 0.988 | 0.0065 |
| MCC Threshold | 0.652 | N/A |
| MCC | 0.7436 | N/A |
| F-score Threshold | 0.426 | N/A |
| F-score | 0.8584 | N/A |