TargetNet
P80365
Corticosteroid 11-beta-dehydrogenase isozyme 2
Function
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Database Links
| Database | Links |
|---|---|
| UniProt | P80365 |
| PDB | Not available |
| BioGrid | 109524 |
| BindingDB | P80365 |
| DrugBank | DB00157 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29477 |
| KEGG | hsa:3291 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3291 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9616 | 0.0039 |
| Accuracy | 0.9058 | 0.0046 |
| Sensitivity | 0.8681 | 0.0104 |
| Specificity | 0.9477 | 0.0073 |
| BEDROC | 0.9999 | 8.2825 × 10-6 |
| MCC Threshold | 0.514 | N/A |
| MCC | 0.8544 | N/A |
| F-score Threshold | 0.514 | N/A |
| F-score | 0.9264 | N/A |