TargetNet
P78536
Disintegrin and metalloproteinase domain-containing protein 17
Function
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Database Links
| Database | Links |
|---|---|
| UniProt | P78536 |
| PDB | 1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T, 3L0V, 3LE9, 3LEA, 3LGP, 3O64 |
| BioGrid | 112731 |
| BindingDB | P78536 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1662 |
| PharmGKB | PA24512 |
| KEGG | hsa:6868 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6868 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9924 | 4.1245 × 10-4 |
| Accuracy | 0.9735 | 0.0015 |
| Sensitivity | 0.9816 | 0.0022 |
| Specificity | 0.9654 | 0.0017 |
| BEDROC | 0.9955 | 0.0024 |
| MCC Threshold | 0.434 | N/A |
| MCC | 0.9486 | N/A |
| F-score Threshold | 0.434 | N/A |
| F-score | 0.9743 | N/A |