Ras-related C3 botulinum toxin substrate 1
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
Database | Links |
---|---|
UniProt | P63001 |
PDB | Not available |
BioGrid | 202556 |
BindingDB | P63001 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | Not available |
KEGG | mmu:19353 |
BioCyc | Not available |
Entrez Gene (GeneID) | 19353 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.7675 | 0.0159 |
Accuracy | 0.7245 | 0.0176 |
Sensitivity | 0.7716 | 0.0212 |
Specificity | 0.6711 | 0.0297 |
BEDROC | 0.91 | 0.0223 |
MCC Threshold | 0.418 | N/A |
MCC | 0.5101 | N/A |
F-score Threshold | 0.418 | N/A |
F-score | 0.7854 | N/A |