Ras-related C3 botulinum toxin substrate 1
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
Database | Links |
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UniProt | P63000 |
PDB | 1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM |
BioGrid | 111817 |
BindingDB | P63000 |
DrugBank | DB00175, DB00641 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA34162 |
KEGG | hsa:5879 |
BioCyc | Not available |
Entrez Gene (GeneID) | 5879 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.8079 | 0.017 |
Accuracy | 0.7577 | 0.0174 |
Sensitivity | 0.7814 | 0.0196 |
Specificity | 0.7333 | 0.0253 |
BEDROC | 0.9018 | 0.0219 |
MCC Threshold | 0.444 | N/A |
MCC | 0.5453 | N/A |
F-score Threshold | 0.356 | N/A |
F-score | 0.7911 | N/A |