TargetNet
P62993
Growth factor receptor-bound protein 2
Function
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Database Links
| Database | Links |
|---|---|
| UniProt | P62993 |
| PDB | 1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H46, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O |
| BioGrid | 109142 |
| BindingDB | P62993 |
| DrugBank | DB00061 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA28962 |
| KEGG | hsa:2885 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2885 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9494 | 0.0042 |
| Accuracy | 0.8945 | 0.0134 |
| Sensitivity | 0.9011 | 0.0201 |
| Specificity | 0.8881 | 0.0105 |
| BEDROC | 0.9928 | 0.0053 |
| MCC Threshold | 0.358 | N/A |
| MCC | 0.8032 | N/A |
| F-score Threshold | 0.358 | N/A |
| F-score | 0.9016 | N/A |