TargetNet
P61073
C-X-C chemokine receptor type 4
Function
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
Database Links
| Database | Links |
|---|---|
| UniProt | P61073 |
| PDB | 2K03, 2K04, 2K05, 3ODU, 3OE0, 3OE6, 3OE8, 3OE9 |
| BioGrid | 113607 |
| BindingDB | P61073 |
| DrugBank | DB00452 |
| Guide to PHARMACOLOGY | 71 |
| PharmGKB | PA27058 |
| KEGG | hsa:7852 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7852 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9564 | 0.0051 |
| Accuracy | 0.8991 | 0.0091 |
| Sensitivity | 0.894 | 0.0128 |
| Specificity | 0.9042 | 0.0107 |
| BEDROC | 0.9913 | 0.0044 |
| MCC Threshold | 0.674 | N/A |
| MCC | 0.8022 | N/A |
| F-score Threshold | 0.44 | N/A |
| F-score | 0.9006 | N/A |