P60953

Cell division control protein 42 homolog

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.

Database Links

Database	Links
UniProt	P60953
PDB	1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK, 2KB0, 2NGR, 2ODB, 2QRZ, 2WM9, 2WMN, 2WMO, 3GCG, 3QBV, 3VHL, 4DID, 4ITR
BioGrid	107433
BindingDB	P60953
DrugBank	Not available
Guide to PHARMACOLOGY	Not available
PharmGKB	PA26266
KEGG	hsa:998
BioCyc	Not available
Entrez Gene (GeneID)	998

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.8648	0.0064
Accuracy	0.7782	0.0133
Sensitivity	0.8016	0.0134
Specificity	0.7509	0.0214
BEDROC	0.9149	0.0227
MCC Threshold	0.69	N/A
MCC	0.6008	N/A
F-score Threshold	0.338	N/A
F-score	0.824	N/A

Downloads

R Model Object

Random Forest model object (.RData)

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Positive Set

SMILES string + affinity value (.tsv)

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TargetNet