TargetNet


P56817

Beta-secretase 1


Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.


Database Links

Database Links
UniProt P56817
PDB 1FKN, 1M4H, 1PY1, 1SGZ, 1TQF, 1UJJ, 1UJK, 1W50, 1W51, 1XN2, 1XN3, 1XS7, 1YM2, 1YM4, 2B8L, 2B8V, 2F3E, 2F3F, 2FDP, 2G94, 2HIZ, 2HM1, 2IQG, 2IRZ, 2IS0, 2NTR, 2OAH, 2OF0, 2OHK, 2OHL, 2OHM, 2OHN, 2OHP, 2OHQ, 2OHR, 2OHS, 2OHT, 2OHU, 2P4J, 2P83, 2P8H, 2PH6, 2PH8, 2Q11, 2Q15, 2QK5, 2QMD, 2QMF, 2QMG, 2QP8, 2QU2, 2QU3, 2QZK, 2QZL, 2VA5, 2VA6, 2VA7, 2VIE, 2VIJ, 2VIY, 2VIZ, 2VJ6, 2VJ7, 2VJ9, 2VKM, 2VNM, 2VNN, 2WEZ, 2WF0, 2WF1, 2WF2, 2WF3, 2WF4, 2WJO, 2XFI, 2XFJ, 2XFK, 2ZDZ, 2ZE1, 2ZHR, 2ZHS, 2ZHT, 2ZHU, 2ZHV, 2ZJH, 2ZJI, 2ZJJ, 2ZJK, 2ZJL, 2ZJM, 2ZJN, 3BRA, 3BUF, 3BUG, 3BUH, 3CIB, 3CIC, 3CID, 3CKP, 3CKR, 3DM6, 3DUY, 3DV1, 3DV5, 3EXO, 3FKT, 3H0B, 3HVG, 3HW1, 3I25, 3IGB, 3IN3, 3IN4, 3IND, 3INE, 3INF, 3INH, 3IVH, 3IVI, 3IXJ, 3IXK, 3K5C, 3K5D, 3K5F, 3K5G, 3KMX, 3KMY, 3KN0, 3KYR, 3L38, 3L3A, 3L58, 3L59, 3L5B, 3L5C, 3L5D, 3L5E, 3L5F, 3LHG, 3LNK, 3LPI, 3LPJ, 3LPK, 3MSJ, 3MSK, 3MSL, 3N4L, 3NSH, 3OHF, 3OHH, 3OOZ, 3PI5, 3QBH, 3QI1, 3R1G, 3R2F, 3RSV, 3RSX, 3RTH, 3RTM, 3RTN, 3RU1, 3RVI, 3S2O, 3S7L, 3S7M, 3SKF, 3SKG, 3TPJ, 3TPL, 3TPP, 3TPR, 3U6A, 3UDH, 3UDJ, 3UDK, 3UDM, 3UDN, 3UDP, 3UDQ, 3UDR, 3UDY, 3UFL, 3UQP, 3UQR, 3UQU, 3UQW, 3UQX, 3VEU, 3VF3, 3VG1, 3VV6, 3VV7, 3VV8, 3WB4, 3WB5, 3ZMG, 3ZOV, 4ACU, 4ACX, 4AZY, 4B00, 4B05, 4B0Q, 4B1C, 4B1D, 4B1E, 4B70, 4B72, 4B77, 4B78, 4BEK, 4BFD, 4D83, 4D85, 4D88, 4D89, 4D8C, 4DH6, 4DI2, 4DJU, 4DJV, 4DJW, 4DJX, 4DJY, 4DPF, 4DPI, 4DUS, 4DV9, 4DVF, 4EWO, 4EXG, 4FCO, 4FGX, 4FM7, 4FM8, 4FRI, 4FRJ, 4FRK, 4FRS, 4FS4, 4FSE, 4FSL, 4GID, 4GMI, 4H1E, 4H3F, 4H3G, 4H3I, 4H3J, 4HA5, 4HZT, 4I0D, 4I0E, 4I0F, 4I0G, 4I0H, 4I0I, 4I0J, 4I0Z, 4I10, 4I11, 4I12, 4I1C, 4IVS, 4IVT, 4J0P, 4J0T, 4J0V, 4J0Y, 4J0Z, 4J17, 4J1C, 4J1E, 4J1F, 4J1H, 4J1I, 4J1K, 4JOO, 4JP9, 4JPC, 4JPE, 4K8S, 4K9H, 4KE0, 4KE1, 4L7G, 4L7H, 4L7J, 4LC7, 4LXA, 4LXK, 4LXM
BioGrid 117154
BindingDB P56817
DrugBank Not available
Guide to PHARMACOLOGY 2330
PharmGKB PA25232
KEGG hsa:23621
BioCyc MetaCyc:ENSG00000160610-MONOMER
Entrez Gene (GeneID) 23621

Chemical Space of the Positive Compounds


Model Performance Metrics

Metric Mean Value Standard Deviation
AUC 0.9843 0.003
Accuracy 0.9629 0.0031
Sensitivity 0.9441 0.0058
Specificity 0.9863 0.0095
BEDROC 1 1.2193 × 10-6
MCC Threshold 0.434 N/A
MCC 0.9393 N/A
F-score Threshold 0.434 N/A
F-score 0.9719 N/A

Downloads

R Model Object

Random Forest model object (.RData)

Download RData

Positive Set

SMILES string + affinity value (.tsv)

Download TSV


Copyright © 2014 - 2017 TargetNet. Developed and maintained by Nan Xiao.

Page generated on: 2014-04-29 14:39:43