TargetNet
P56658
Adenosine deaminase
Function
Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P56658 |
| PDB | 1KRM, 1NDV, 1NDW, 1NDY, 1NDZ, 1O5R, 1QXL, 1UML, 1V79, 1V7A, 1VFL, 1W1I, 1WXY, 1WXZ, 2BGN, 2E1W, 2Z7G |
| BioGrid | Not available |
| BindingDB | P56658 |
| DrugBank | DB00061 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:280712 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 280712 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9091 | 0.008 |
| Accuracy | 0.8411 | 0.0117 |
| Sensitivity | 0.8282 | 0.0181 |
| Specificity | 0.8524 | 0.0111 |
| BEDROC | 0.9204 | 0.0288 |
| MCC Threshold | 0.512 | N/A |
| MCC | 0.7188 | N/A |
| F-score Threshold | 0.512 | N/A |
| F-score | 0.8509 | N/A |