TargetNet
P56524
Histone deacetylase 4
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Database Links
| Database | Links |
|---|---|
| UniProt | P56524 |
| PDB | 2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY |
| BioGrid | 115106 |
| BindingDB | P56524 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29229 |
| KEGG | hsa:9759 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 9759 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9287 | 0.004 |
| Accuracy | 0.865 | 0.0118 |
| Sensitivity | 0.8811 | 0.0123 |
| Specificity | 0.8473 | 0.0222 |
| BEDROC | 0.974 | 0.014 |
| MCC Threshold | 0.352 | N/A |
| MCC | 0.7863 | N/A |
| F-score Threshold | 0.352 | N/A |
| F-score | 0.9013 | N/A |