TargetNet
P56481
Gastrin/cholecystokinin type B receptor
Function
Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P56481 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P56481 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 77 |
| PharmGKB | Not available |
| KEGG | mmu:12426 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 12426 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.982 | 0.0021 |
| Accuracy | 0.9548 | 0.0039 |
| Sensitivity | 0.936 | 0.0061 |
| Specificity | 0.9708 | 0.0055 |
| BEDROC | 0.9969 | 0.0039 |
| MCC Threshold | 0.36 | N/A |
| MCC | 0.9393 | N/A |
| F-score Threshold | 0.36 | N/A |
| F-score | 0.9672 | N/A |