TargetNet
P56450
Melanocortin receptor 4
Function
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Database Links
| Database | Links |
|---|---|
| UniProt | P56450 |
| PDB | Not available |
| BioGrid | 201341 |
| BindingDB | P56450 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 285 |
| PharmGKB | Not available |
| KEGG | mmu:17202 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 17202 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9299 | 0.0042 |
| Accuracy | 0.8838 | 0.0135 |
| Sensitivity | 0.8786 | 0.0234 |
| Specificity | 0.8893 | 0.0062 |
| BEDROC | 0.9665 | 0.0194 |
| MCC Threshold | 0.514 | N/A |
| MCC | 0.7905 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.8974 | N/A |