TargetNet
P55212
Caspase-6
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Database Links
| Database | Links |
|---|---|
| UniProt | P55212 |
| PDB | 1MI9, 2WDP, 3K7E, 3NKF, 3NR2, 3OD5, 3P45, 3P4U, 3QNW, 3S70, 3S8E, 3V6L, 3V6M, 4EJF, 4FXO, 4HVA, 4IYR, 4N5D, 4N6G, 4N7J, 4N7M, 4NBK, 4NBL, 4NBN |
| BioGrid | 107289 |
| BindingDB | P55212 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1622 |
| PharmGKB | PA26090 |
| KEGG | hsa:839 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 839 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8887 | 0.0078 |
| Accuracy | 0.8243 | 0.0139 |
| Sensitivity | 0.8547 | 0.0234 |
| Specificity | 0.7879 | 0.022 |
| BEDROC | 0.9809 | 0.0066 |
| MCC Threshold | 0.522 | N/A |
| MCC | 0.6842 | N/A |
| F-score Threshold | 0.522 | N/A |
| F-score | 0.8551 | N/A |