TargetNet
P55211
Caspase-9
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Database Links
| Database | Links |
|---|---|
| UniProt | P55211 |
| PDB | 1JXQ, 1NW9, 2AR9, 3D9T, 3V3K, 3YGS |
| BioGrid | 107292 |
| BindingDB | P55211 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1625 |
| PharmGKB | PA26094 |
| KEGG | hsa:842 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 842 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7752 | 0.009 |
| Accuracy | 0.7185 | 0.0109 |
| Sensitivity | 0.6353 | 0.0155 |
| Specificity | 0.793 | 0.018 |
| BEDROC | 0.9032 | 0.012 |
| MCC Threshold | 0.546 | N/A |
| MCC | 0.5 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.7024 | N/A |