TargetNet
P55210
Caspase-7
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
Database Links
| Database | Links |
|---|---|
| UniProt | P55210 |
| PDB | 1F1J, 1GQF, 1I4O, 1I51, 1K86, 1K88, 1KMC, 1MIA, 1SHJ, 1SHL, 2QL5, 2QL7, 2QL9, 2QLB, 2QLF, 2QLJ, 3EDR, 3H1P, 3IBC, 3IBF, 3R5K, 4FDL, 4FEA, 4HQ0, 4HQR, 4JB8, 4JJ8, 4JR1, 4JR2 |
| BioGrid | 107290 |
| BindingDB | P55210 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1623 |
| PharmGKB | PA26091 |
| KEGG | hsa:840 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 840 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9691 | 0.0024 |
| Accuracy | 0.9316 | 0.007 |
| Sensitivity | 0.9476 | 0.0095 |
| Specificity | 0.9118 | 0.0079 |
| BEDROC | 0.9976 | 0.0012 |
| MCC Threshold | 0.46 | N/A |
| MCC | 0.876 | N/A |
| F-score Threshold | 0.46 | N/A |
| F-score | 0.9454 | N/A |