Mitogen-activated protein kinase 10
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Database | Links |
---|---|
UniProt | P53779 |
PDB | 1JNK, 1PMN, 1PMQ, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B |
BioGrid | 111588 |
BindingDB | P53779 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 1498 |
PharmGKB | PA30617 |
KEGG | hsa:5602 |
BioCyc | Not available |
Entrez Gene (GeneID) | 5602 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9002 | 0.0053 |
Accuracy | 0.8325 | 0.0068 |
Sensitivity | 0.8382 | 0.0074 |
Specificity | 0.8255 | 0.0116 |
BEDROC | 0.9729 | 0.0085 |
MCC Threshold | 0.598 | N/A |
MCC | 0.6705 | N/A |
F-score Threshold | 0.476 | N/A |
F-score | 0.8453 | N/A |