TargetNet
P53609
Geranylgeranyl transferase type-1 subunit beta
Function
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.
Database Links
| Database | Links |
|---|---|
| UniProt | P53609 |
| PDB | Not available |
| BioGrid | 111250 |
| BindingDB | P53609 |
| DrugBank | DB00175 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33233 |
| KEGG | hsa:5229 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5229 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9323 | 0.0041 |
| Accuracy | 0.8769 | 0.0072 |
| Sensitivity | 0.8867 | 0.0121 |
| Specificity | 0.8674 | 0.0091 |
| BEDROC | 0.951 | 0.0157 |
| MCC Threshold | 0.598 | N/A |
| MCC | 0.7427 | N/A |
| F-score Threshold | 0.598 | N/A |
| F-score | 0.8621 | N/A |