TargetNet
P52732
Kinesin-like protein KIF11
Function
Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.
Database Links
| Database | Links |
|---|---|
| UniProt | P52732 |
| PDB | 1II6, 1Q0B, 1X88, 1YRS, 2FKY, 2FL2, 2FL6, 2FME, 2G1Q, 2GM1, 2IEH, 2PG2, 2Q2Y, 2Q2Z, 2UYI, 2UYM, 2WOG, 2X2R, 2X7C, 2X7D, 2X7E, 2XAE, 3CJO, 3HQD, 3K3B, 3K5E, 3KEN, 3L9H, 3ZCW, 4A1Z, 4A28, 4A50, 4A51, 4A5Y, 4AP0, 4AQV, 4AQW, 4AS7, 4B7B, 4BBG, 4BXN |
| BioGrid | 110030 |
| BindingDB | P52732 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA30177 |
| KEGG | hsa:3832 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3832 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9615 | 0.0027 |
| Accuracy | 0.9028 | 0.006 |
| Sensitivity | 0.9115 | 0.0062 |
| Specificity | 0.895 | 0.007 |
| BEDROC | 0.9753 | 0.0043 |
| MCC Threshold | 0.4 | N/A |
| MCC | 0.8201 | N/A |
| F-score Threshold | 0.4 | N/A |
| F-score | 0.9076 | N/A |