TargetNet
P51685
C-C chemokine receptor type 8
Function
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Database Links
| Database | Links |
|---|---|
| UniProt | P51685 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P51685 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 65 |
| PharmGKB | PA26173 |
| KEGG | hsa:1237 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1237 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9659 | 0.0052 |
| Accuracy | 0.9437 | 0.0038 |
| Sensitivity | 0.9396 | 0.0087 |
| Specificity | 0.9478 | 0.005 |
| BEDROC | 0.9813 | 0.0148 |
| MCC Threshold | 0.542 | N/A |
| MCC | 0.8982 | N/A |
| F-score Threshold | 0.526 | N/A |
| F-score | 0.947 | N/A |