TargetNet
P51681
C-C chemokine receptor type 5
Function
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Database Links
| Database | Links |
|---|---|
| UniProt | P51681 |
| PDB | 1ND8, 1NE0, 1OPN, 1OPT, 1OPW, 2L87, 2RLL, 2RRS, 4MBS |
| BioGrid | 107639 |
| BindingDB | P51681 |
| DrugBank | DB04835 |
| Guide to PHARMACOLOGY | 62 |
| PharmGKB | PA26170 |
| KEGG | hsa:1234 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1234 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9894 | 4.2587 × 10-4 |
| Accuracy | 0.9651 | 0.0015 |
| Sensitivity | 0.9643 | 0.0022 |
| Specificity | 0.9658 | 0.0021 |
| BEDROC | 0.9963 | 0.0017 |
| MCC Threshold | 0.506 | N/A |
| MCC | 0.9328 | N/A |
| F-score Threshold | 0.506 | N/A |
| F-score | 0.9636 | N/A |