TargetNet
P51679
C-C chemokine receptor type 4
Function
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Database Links
| Database | Links |
|---|---|
| UniProt | P51679 |
| PDB | Not available |
| BioGrid | 107638 |
| BindingDB | P51679 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 61 |
| PharmGKB | PA26169 |
| KEGG | hsa:1233 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1233 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9122 | 0.0052 |
| Accuracy | 0.8451 | 0.008 |
| Sensitivity | 0.8619 | 0.0122 |
| Specificity | 0.8276 | 0.0139 |
| BEDROC | 0.9764 | 0.0107 |
| MCC Threshold | 0.36 | N/A |
| MCC | 0.7063 | N/A |
| F-score Threshold | 0.36 | N/A |
| F-score | 0.8634 | N/A |