TargetNet
P51677
C-C chemokine receptor type 3
Function
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Database Links
| Database | Links |
|---|---|
| UniProt | P51677 |
| PDB | Not available |
| BioGrid | 107637 |
| BindingDB | P51677 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 60 |
| PharmGKB | PA26168 |
| KEGG | hsa:1232 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1232 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.987 | 8.5978 × 10-4 |
| Accuracy | 0.9568 | 0.0019 |
| Sensitivity | 0.9611 | 0.0027 |
| Specificity | 0.9521 | 0.0029 |
| BEDROC | 0.9987 | 7.732 × 10-4 |
| MCC Threshold | 0.472 | N/A |
| MCC | 0.9176 | N/A |
| F-score Threshold | 0.472 | N/A |
| F-score | 0.9616 | N/A |