TargetNet
P51661
Corticosteroid 11-beta-dehydrogenase isozyme 2
Function
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Database Links
| Database | Links |
|---|---|
| UniProt | P51661 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P51661 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | mmu:15484 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 15484 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9857 | 0.0029 |
| Accuracy | 0.9543 | 0.004 |
| Sensitivity | 0.9373 | 0.0068 |
| Specificity | 0.975 | 0.0062 |
| BEDROC | 1 | 1.604 × 10-6 |
| MCC Threshold | 0.62 | N/A |
| MCC | 0.9274 | N/A |
| F-score Threshold | 0.62 | N/A |
| F-score | 0.9646 | N/A |